Re: ICC profiles
Yes you can using ArgyllCMS to calibrate and profile your monitors. Then using software like CinePaint or Krita you can use the monitor profiles created with ArgyllCMS along with the profiles for your input devices (cameras ans scanners) have a full color managed work flow.
One word of caution. You can't use the ArgyllCMS monitor calibration with nvidia twinview. But it should work with Xinerama.