Originally Posted by doctor_octagon
Things are looking promising. After noticing that someone on the 2.6.18 kernel was having similar issues I upgraded my FC6 box to 2.6.20 and the box has been running for 3 days without experiencing the same issue.
I also disabled irqbalance at the same time, so there's two variables, but I'll try turning on irqbalance again in a few days and see how that goes. My guess is that if it's fixed (cross your fingers) it was the kernel that fixed it.
Just an update for anyone who finds this thread - my uptime is over 6 days now so I think I'm going to say it's fixed. Thanks to all who replied.