I'm happy to report that after installing 169.04 and removing the 'maxcpus=1' kernel boot option, I played 5 hours of World of Warcraft through wine without a single problem!
I'm running the following:
Fedora 8 x86_64
Intel(R) Core(TM)2 CPU 6300 @ 1.86GHz
GeForce 7300 LE
Asus P5NSLI Motherboard