Just finished the game for the first time. It's definitely one of the few games that I've played that is worth a replay. The story is seriously epic. I encountered a few glitches, but nothing serious. My support team would occasionally freeze, sound glitching and recurring sounds happened a couple times at least, and an elevator froze on me once. Fortunately, all of these things corrected themselves by reloading the level from the main menu.
Good job Bioware! Kick ass game indeed!