Originally Posted by azenz
Regarding putting nvidia-settings -l in the desktop manager, does that mean that this command can be run after the x-server was started?
When you make changes through nvidia-settings (such as opengl settings, sync to vblank etc.) they changes are saved in your ~/.nvidia-settings-rc file. In order to apply these settings after starting X, you need to run nvidia-settings with the -l switch so it loads and applies those settings.