Very important notice for the HD textures
In the classic BloodRayne 2 start menu, you MUST select:
Texture detail: High (slower) (VERY IMPORTANT)
If you do not select this, the patch won't be able to replace the textures of the game on the fly.
About the rest of options, and to avoid problems, remember to set:
Bump mapping: On (slower)
Dynamic shadows: On (slower)
Reflections: On (slower)
Also, if you use a custom resolution from the patch, i recommend to set "in this menu", the resolution to 640 x 480. Do not worry, the patch will force your selected resolution.
Hope this helps !