Re: GTx 280 pink screen crash on first running 3D game from 2-3 hours rest.
Sometimes the root cause failure, say, over in your system memory, could result in symptoms of a crashing video driver.
Very doubtful it's the HDD or DVD. Most likely the GPU. However, you could try reseating the memory, the cpu, the gpu card, the data cables, the power connectors. If you have 2 sticks of ram, run with just one, and then with just the other. Try relaxing ram timings. Try an extra notch of cpu and ram voltage (safely of course). Probably none of this will help -- but -- you never know.
I bet if you plugged in an identical video card of the one you have, the problem would go away.