Originally Posted by Felix.K
I've tried disabling xinerama and suddenly the problem disappeared.
So it seems to be a problem with xinerama and the NVIDIA driver.
The wine developers think its a driver problem, see:
i had the same problem when using xinerama, have since not been using xinerama since 180.22 or so and not had the problem....
the mouse hang in xinerama was more annoying tbh but atleast it had a work around...
also in my case i gain about 25% performance from not using xinerama as well...