My VID is 1.2500V and my Q6600 G0 is currently OC'ed to the speed in my sig!
It is very relaistic... but keep in mind your memory might hold you back... I had to move to the RAM in my sig from the 4 sticks of DD2-800 I had before. Could have been to much stress on the NB or just crappy ram. Either way... I managed 3.7Ghz stable on this rig, but it ran pretty hot so I took it down to the speed I have listed now
Good luck and keep us posted! I run Orthos and max out all cores that way by setting the affinity of that program instance for the 4 cores on the CPU.