Originally Posted by Dazz
Working for Cyberpower System we have experimented with it, 3 way SLI will not work and folding on a 3 way SLI board will also mean much much lower performance. We found on a X48 board or a Crossfire board Folding performance is almost doubled. one of the cards dual GPU's will refuse to work correctly on SLI motherboards. Just a word of advice, as we build high end gaming systems and folding systems for medial research and data centres.
Folding performance is definitely not lower with 6 gpus if you use them correctly.