Originally Posted by TheBlackCat
Nvidia's settings, on the other hand, are lost on reboot unless you make changes to you Xorg.conf file, and such settings are global and require root access. There is no user-level settings at all.
In the nvidia settings tool, go down to 'nvidia-settings Configuration', click 'save current configuration', save the file (.nvidia-settings-rc) in your home folder.
Add "nvidia-settings -l" to your startup applications in whatever desktop environment you use.
Done, per user settings that are applied at log in for that user and of course persist through reboot.