How many places are you going to post this?
Just max it out, start playing, then tweak the settings as needed for smooth gameplay. On the rig in my sig at 1680x1050 I have everything maxed, but DoF under DX11 and physics disabled, and AF at 4...game is smooth as butter.
As you are running a higher rez you might be able to drop the MSAA to AAA, which will help a lot.
just play and tweak.