So far I'm very impressed. game doesn't give me the feeling of the vast wide open hugeness that FO3 originally did. I know that it's there but everything so far feels like it's all contained in this small valley with the prison and the powderkeggers and what not.
Finding decent weapons is much more difficult in this one. I was rocking the 9mm pistol and the "Varmint killer" for easily several hours before I stumbled upon "lucky" the 357 magnum at the Bison Steve's in a safe on the floor panel behind a counter. Hard lock.. though.
Does massive damage!
Game runs great though. Everything is maxed out at 1900X1200 and it stays glued to 60 fps.
EDIT: And not ONE crash to desktop (knock on wood)