OpenGL, 1152x864x32, Quincux FSAA, all details maxed, physics set to normal. Getting around 45-60 fps depending on the map. I could play at 1600x1200 or 1280x1024 with no FSAA but I choose not to. System specs are in the link in my sig.
This was with the 40.71 dets, btw. I've not had a chance to try the game with the newly released 40.72's.