sorry to bump this old thread. But I have a very similar problem with wine and Diablo II and glide-wrapper.
Quakelive (750FPS 1920x1080) and doom3 (175FPS 1920x1080, Ultra Quality) runs smooth on my gentoo-linux.
Linux Kernel 3.0.0-gentoo
Intel i7 2600
Gigabyte nVidia Geforce 590
Tried the drivers 270.41.06, 275.09.07, 275.19 and 280.11
Take a look here:
I will attach the nvidia bug report log when I get home from work.