Re: Resident Evil 4 & 5 crashing to desktop after start up
Use Run > Msconfig and start disabling unnecessary services and startup programs till it starts. if your using Asus smartdoctor or similar software disable it due to it can make certain games crash on startup. Its most likely a program you are running on your machine. In RE5 when you boot configure the options to boot on a low resolution and graphics settings. RE5 can bring some heat to some machines of the age you have.
CPU - I7 2600K 4.5 GHZ
RAM - 8 GB DDR3 1600mhz
GPU - GTX 570 Classified