Re: 6111 nvidia-settings adjustments won't stick
I'm not sure if the problem is a Nvidia bug as I will explain now. The nvidia-settings tool can roughly set two types of options.
First it can adjust NV-CONTROL options which are things like Vsync, FSAA, Aniso filtering and settings like that. Further the other options it can set are generic X things like Xv, gamma, brightness and more for which "normal" X extensions are used. With which of the options did you have problems?
Further games and other apps like to adjust gamma themself, so that might undo your gamma too.