It doesn't matter what resolution you have, you can draw a perfect freggin' circle all the time. The only way something is going to get skewed is if the program is stretching the image to fit the screen and im not aware of any graphics programs that would do such a silly thing. Maybe a CAD program does it, but I don't know why, that would be rather stupid.
Also, I guess all of our magazines should have skewed pictures and design as layout artist for magazines tend to use non-traditional aspect monitors to do their layout work. Same goes for some CAD designers.
Also, in games, nothing will get skewed. or else anyone with 3 monitors hooked up playing Q3 would get a headache. The only thing that might get skewed or spaced out is a 2D GUI. Anachronox is a good example is you edit the resolution in the config file for use something else other that 640x480 or 1280x960.
THE RESOLUTION IS JUST A WINDOW INTO THE SAME STUFF!!!